Hb La Desirade	beta129(H7)Ala->Val

CONTACT		Internal
HEMATOLOGY		Probably normal in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A by standard procedures; Hb X was slightly more anodal than Hb A on IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCC->GTC at codon 129
FUNCTION STUDIES		Decreased oxygen affinity
STABILITY		Unstable
OCCURRENCE		Found in two unrelated Black families
OTHER INFORMATION		Occurred in combination with betao-thal and with Hb C

REFERENCES
1.		Merault, G., Keclard, L., Garin, J., Poyart, C., Blouquit, Y., Arous, N., Galacteros, F., Feingold, J., and Rosa, J.; Hemoglobin, 10:593, 1986.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.