Hb Kodaira	beta146(HC3)His->Gln

CONTACT		External; alpha2beta1 contact
HEMATOLOGY		Normal? The carrier was anemic because of an unrelated cause
ELECTROPHORESIS		Hb X was detected by IEF; Hb X moves slightly more anodic than Hb A
CHROMATOGRAPHY		Not reported; the betaX and betaA chains separated by CM-cellulose chromatography (elution order: betaX, betaA, alpha)
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		A CAC->CAA mutation at codon 146
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a 75-year-old Japanese male
OTHER INFORMATION		Quantity in the carrier was 49%

REFERENCES
1.		Harano, T., Harano, K., Kushida, Y., Imai, K., Nishinakamura, R., and Matsunaga, T.: Hemoglobin, 16:85, 1992.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.