Hb Khartoum	beta124(H2)Pro->Arg

CONTACT		External; alpha1beta1 contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves like Hb S
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of the AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CCA->CGA at codon 124
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a male from Khartoum; family was not available for study
OTHER INFORMATION		Quantity in the heterozygote 30%

REFERENCES
1.		Clegg, J.B., Weatherall, D.J., Wong, H.B., and Mustafa, D.: Nature, 22:379, 1969.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.