Hb J-Kaohsiung	beta59(E3)Lys->Thr

ALSO KNOWN AS		J-Honolulu
CONTACT		External
HEMATOLOGY		Not reported
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (Hb X is fast moving) but not at acidic pH
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; CNBr; carboxypeptidase B digestion for C-terminal determination
DNA ANALYSES		Not reported; presumed mutation AAG->ACG at codon 59
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a few Chinese families
OTHER INFORMATION		Quantity in the heterozygote 47%

REFERENCES
1.		Blackwell, R.Q., Liu, C-S., and Shih, T-B.: Biochim. Biophys. Acta, 229:343, 1971.
2.		Shih, T-B.: Vox Sang., 22:469, 1972.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.