Hb J-Bangkok	beta56(D7)Gly->Asp

ALSO KNOWN AS		J-Meinung; J-Korat; J-Manado
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A can be separated at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; CNBr; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GGC->GAC at codon 56
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in Thai, Indonesian, Black, and Chinese families
OTHER INFORMATION		Quantity in the heterozygote 40-45%; also found in combination with Hb S

REFERENCES
1.		Clegg, J.B., Naughton, M.A., and Weatherall, D.J.: J. Mol. Biol., 19:91, 1966.
2.		Blackwell, R.Q. and Liu, C-S.: Biochem. Biophys. Res. Commun., 24:732, 1966.
3.		Pootrakul, S., Wasi, P., and Na-Nakorn, S.: Br. J. Haematol., 13:303, 1967.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.