Hb J-Altgeld Gardens	beta92(F8)His->Asp

CONTACT		Heme contact; proximal histidine
HEMATOLOGY		Mild anemia in the proband who had Hb X-betao-thal
ELECTROPHORESIS		Hb X moves faster than Hb A at alkaline pH
CHROMATOGRAPHY		Not reported; the betaX and betaA chains readily separate by CM-cellulose chromatography (the Clegg method)
STRUCTURE STUDIES		Tryptic digestion of the betaX chain; separation of peptides by fingerprinting; cation exchange chromatography; glycinamidation; amino acid analysis; formic acid
DNA ANALYSES		Not reported; presumed mutation CAC->GAC at codon 92
FUNCTION STUDIES		Normal oxygen affinity; cooperativity slightly decreased
STABILITY		Mildly unstable
OCCURRENCE		Found in a 21-year-old Black female and her son living in Chicago, Illinois, USA
OTHER INFORMATION		Methemoglobinemia was absent

REFERENCES
1.		Adams, J.G., III, Przywara, K.P., Heller, P., and Shamsuddin, M.: Hemoglobin, 2:403, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.