Hb I-High Wycombe	beta59(E3)Lys->Glu

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X is fast moving
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation AAG->GAG at codon 59
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an English family and in a Australian family of German and Scottish descent
OTHER INFORMATION		Quantity in the heterozygote ~45%

REFERENCES
1.		Boulton, F.E., Huntsman, R.G., Lehmann, H., Lorkin, P., and Romero Herrera, A.E.: Br. J. Haematol., 20:671, 1971.
2.		Wilkinson, T., Como, P., Brock, P., Kronenburg, H., Trent, R.J.A., and Brennan, S.O.: Hemoglobin, 11:51, 1987.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.