Hb Hradec Kralove (or HK)	beta115(G17)Ala->Asp

CONTACT		Internal; alpha1beta1 contact
HEMATOLOGY		Moderate hemolytic anemia in the heterozygote; reticulocytosis
ELECTROPHORESIS		Hb X was not detected by any standard technique or by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Not reported
DNA ANALYSES		A GCC->GAC mutation at codon 115
FUNCTION STUDIES		Not reported
STABILITY		Very unstable
OCCURRENCE		Found in a 32-year-old Czech woman and her daughter
OTHER INFORMATION		This is a thalassemic Hb that is most difficult to detect except by DNA sequencing

REFERENCES
1.		Divoky, V., Svobodova, M., Indrak, K., Chrobak, L., Molchanova, T.P., and Huisman, T.H.J.: Hemoglobin, 17:319, 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.