Hb Hikari	beta61(E5)Lys->Asn

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X has a mobility like Hb J
CHROMATOGRAPHY		Hb X and Hb A can be separated by different types of cation or anion exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; pronase digestion
DNA ANALYSES		Not reported; presumed mutation AAG->AAC or AAT at codon 61
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a few Japanese families
OTHER INFORMATION		Quantity in the heterozygote ~45%

REFERENCES
1.		Shibata, S., Miyaji, T., Iuchi, I., Ueda, S., and Takeda, I.: Clin. Chim. Acta, 10: 101, 1964.
2.		Nakatsuji, T., Miwa, S., Hattori, Y., Ohba, Y., Miyaji, T., Miyata, H., Shinohara, T., and Matsui, Y.: Hemoglobin, 5:487, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.