Hb Henri Mondor | beta26(B8)Glu->Val |
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CONTACT | External | ||
HEMATOLOGY | Mild hypochromic microcytic anemia in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A2 can be separated at alkaline pH; Hb X moves between Hb F and Hb S | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-Sephadex chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; fingerprinting; cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GTG at codon 26 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Slightly unstable | ||
OCCURRENCE | Found in a 9-year-old African female | ||
OTHER INFORMATION | Quantity in the heterozygote 37.5% |
REFERENCES | |||
1. | Blouquit, Y., Arous, N., Machado, P.E.A., and Garel, M.C.: FEBS Lett., 72:5, 1976. |