Hb Headington	beta72(E16)Ser->Arg

CONTACT		External
HEMATOLOGY		Mild erythrocytosis in the proband who also had a (deltabeta)o-thal
ELECTROPHORESIS		Hb X occupies the position of Hb S at alkaline pH; excellent separation by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Not reported; identification was by DNA analysis
DNA ANALYSES		An AGT->AGA mutation at codon 72
FUNCTION STUDIES		Increase in oxygen affinity; slight decrease in cooperativity; Bohr effect normal
STABILITY		Normal
OCCURRENCE		Found in an Asian Indian family
OTHER INFORMATION		Occurred in combination with a (deltabeta)o-thal

REFERENCES
1.		Rochette, J., Barnetson, R., Kiger, L., Kister, J., Littlewood, T.J., Webster, R., Poyart, C., and Thein, S.L.: Br. J. Haematol., 86:118, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.