Hb Hamadan | beta56(D7)Gly->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH (Hb X occupies the position of Hb S) | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-cellulose chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GGC->CGC at codon 56 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in three members of an Iranian family, a French Caucasian family, and in four members of a family of Turkish descent | ||
OTHER INFORMATION | Quantity in the heterozygote 40% |
REFERENCES | |||
1. | Rahbar, S., Nowzari, G., Haydari, H., and Daneshmand, P.: Biochim. Biophys. Acta, 379:645, 1975. | ||
2. | Dinçol, G., Aksoy, M., Dinçol, K., Kutlar, A., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:423, 1984. |