Hb Gainesville-GA	beta46(CD5)Gly->Arg

CONTACT		External
HEMATOLOGY		Observed in two healthy newborn babies; data from heterozygous parents not available
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (it moves as Hb S) but not at acidic pH
CHROMATOGRAPHY		Originally isolated by DEAE-cellulose chromatography; also excellent separations by cation exchange HPLC
STRUCTURE STUDIES		Tryptic digestion of betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGG->AGG at codon 46
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a few Black newborns living in North Georgia
OTHER INFORMATION		Quantity in the heterozygote 36-37%

REFERENCES
1.		Chen, S.S., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9: 179, 1985.
2.		Wilson, J.B., Webber, B.B., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 13: 623, 1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.