Hb G-Taipei	beta22(B4)Glu->Gly

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves about as Hb S
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation exchange HPLC; the betaA and betaX chains separate completely by reversed phase HPLC
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAA->GGA at codon 22
FUNCTION STUDIES		Not reported
STABILITY		Stable
OCCURRENCE		Found in a few Chinese families
OTHER INFORMATION		Quantity in the heterozygote 36-40%

REFERENCES
1.		Blackwell, R.Q., Yang, H.J., and Wang, C.C.: Biochim. Biophys. Acta, 174: 237, 1969.
2.		Landman, H., Wilson, J.B., Kutlar, A., Gonzalez Redondo, J.M., and Huisman, T.H.J.: Hemoglobin, 11:169, 1987.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.