Hb G-Siriraj	beta7(A4)Glu->Lys

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves between Hb S and Hb F (Tris buffer) and between Hb A2 and Hb S (barbiturate buffer) on paper at alkaline pH; Hb X moves between Hb E and Hb S on starch gel at alkaline pH, and as Hb C on citrate agar at acidic pH
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation and anion exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; carboxypeptidase B used to determine the C-terminal amino acid of peptide betaT-1
DNA ANALYSES		Not reported; presumed mutation GAG->AAG at codon 7
FUNCTION STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a few Thai and Chinese families
OTHER INFORMATION		Quantity in heterozygotes 33-40%; the variant has been found in combination with beta-thal and in a homozygote (Ref. 3)

REFERENCES
1.		Tuchinda, S., Beale, D., and Lehmann, H.; Br. Med. J., 1:1583, 1965.
2.		Blackwell, R.Q., Liu, C-S., and Wang, C-L.: Vox Sang., 23:433, 1972.
3.		Zeng, Y. and Huang, S.; Acta Genet. Sin., 6:155, 1979.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.