Hb G-Makassar	beta6(A3)Glu->Ala

CONTACT		External
HEMATOLOGY		Presumed normal in the heterozygote
ELECTROPHORESIS		Hb X moves to position of Hb S on starch gel at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAG->GCG at codon 6
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an Indonesian family from Southwest Sulawesi
OTHER INFORMATION		Quantity in the heterozygote ~45%; no sickling reported

REFERENCES
1.		Blackwell, R.Q., Oemijati, S., Pribadi, W., Weng, M-I., and Liu, C-S.: Biochim. Biophys. Acta, 214:396, 1970.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.