Hb G-Galveston	beta43(CD2)Glu->Ala

ALSO KNOWN AS		G-Port Arthur; G-Texas
CONTACT		External
HEMATOLOGY		Normal in heterozygotes
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH where Hb G is slightly faster than Hb S, and at acidic pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->GCG at codon 43
FUNCTION STUDIES		Normal
STABILITY		Not reported
OCCURRENCE		Found in a few Black families, including a homozygote; a father and nine children; a mother and five children, and a Black male with a compound heterozygosity for Hb G and Hb S
OTHER INFORMATION		Quantity in heterozygotes 50%; the homozygote is healthy

REFERENCES
1.		Edington, G.M., Lehmann, H., and Schneider, R.G.: Nature, 175:850, 1955.
2.		Bowman, B.H., Moreland, H., and Schneider, R.G.: Nature, 193:1298, 1960.
3.		McCurdy, P.R., Lorkin, P.A., Casey, R., Lehmann, H., Uddin, D.E., and Dickson, L.G.: Am. J. Med., 57:665, 1974.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.