Hb G-Coushatta	beta22(B4)Glu->Ala

ALSO KNOWN AS		G-Saskatoon; G-Hsin Chu; G-Taegu
CONTACT		External
HEMATOLOGY		Normal in the heterozygote and homozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves about as Hb S
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAA->GCA at codon 22
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Observed in Indians, Chinese, Koreans, Japanese, Turks, Algerians, etc.
OTHER INFORMATION		Quantity in the heterozygote 38-45%; a homozygote has been detected; also observed in combination with beta-thal

REFERENCES
1.		Vella, F., Isaacs, W.A., and Lehmann, H.: Can. J. Biochem., 45:351, 1967.
2.		Blackwell, R.Q., Ro, I-H., Liu, C-S., Yang, H-J., Wang, C-C., and Huang, J.T-H.: Am. J. Phys. Anthropol., 30:389, 1969.
3.		Dinçol, G., Dinçol, K., and Erdem, S.: Hemoglobin, 13:75-1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.