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ALSO KNOWN AS | |
G-Saskatoon; G-Hsin Chu; G-Taegu | |
CONTACT | |
External | |
HEMATOLOGY | |
Normal in the heterozygote and homozygote | |
ELECTROPHORESIS | |
Hb X and Hb A separate at alkaline pH; Hb X moves about as Hb S | |
CHROMATOGRAPHY | |
Hb X and Hb A can be separated by cation and anion exchange chromatography | |
STRUCTURE STUDIES | |
Tryptic digestion; fingerprinting; reversed phase HPLC; amino acid analysis; sequencing | |
DNA ANALYSES | |
Not reported; presumed mutation GAA->GCA at codon 22 | |
FUNCTION STUDIES | |
Normal | |
STABILITY | |
Normal | |
OCCURRENCE | |
Observed in Indians, Chinese, Koreans, Japanese, Turks, Algerians, etc. | |
OTHER INFORMATION | |
Quantity in the heterozygote 38-45%; a homozygote has been detected; also observed in combination with beta-thal | |
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REFERENCES |
1. | |
Vella, F., Isaacs, W.A., and Lehmann, H.: Can. J. Biochem., 45:351, 1967. | |
2. | |
Blackwell, R.Q., Ro, I-H., Liu, C-S., Yang, H-J., Wang, C-C., and Huang, J.T-H.: Am. J. Phys. Anthropol., 30:389, 1969. | |
3. | |
Dinçol, G., Dinçol, K., and Erdem, S.: Hemoglobin, 13:75-1989. | |