Hb D-Ibadan	beta87(F3)Thr->Lys

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH (Hb X has the mobility of Hb S); at acidic pH Hb X moves slightly slower than Hb A but much faster than Hb S
CHROMATOGRAPHY		Hb X and Hb A separate in both cation and anion exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin; sequencing
DNA ANALYSES		Not reported; presumed mutation ACA->AAA at codon 87
FUNCTION STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a few Nigerian families and in a Black male in the USA
OTHER INFORMATION		Quantity in the heterozygote 41%; found in combination with Hb S and with deltabeta-thal

REFERENCES
1.		Watson-Williams, E.J., Beale, D., Irvine, D., and Lehmann, H.: Nature, 205:1273, 1965.
2.		Falusi, A.G., Ogunmola, G.B., and Esan, G.J.F.: Clin. Res., 25:338A, 1977.
3.		Rucknagel, D.L.: Hemoglobin, 3:77, 1979.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.