Hb Cook	beta132(H10)Lys->Thr

CONTACT		External; near central cavity
HEMATOLOGY		About normal in the heterozygote
ELECTROPHORESIS		Hb X is slightly faster than Hb A at alkaline pH; Hb X moves like Hb F at acidic pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Not reported
DNA ANALYSES		An AAA->ACA mutation at codon 132
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a 28-year-old Thai female
OTHER INFORMATION		Quantity in the heterozygote ~55%

REFERENCES
1.		Hutt, P.J., Griffin, T., Fairbanks, V., Hoyer, J., and Thibodeau, S.: Blood, 86: 649a (Suppl. 1), 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.