Hb Collingwood | beta60(E4)Val->Ala |
---|
CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | No separation of Hb X and Hb A observed at alkaline pH; no separation by IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GTG->GCG at codon 60 | ||
FUNCTION STUDIES | Normal oxygen affinity | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in Greek male | ||
OTHER INFORMATION | Quantity in the heterozygote 41% |
REFERENCES | |||
1. | Williamson, D., Brennan, S.O., Muir, H., and Carrell, R.W.: Hemoglobin, 7:511, 1983. |