Hb Borås	beta88(F4)Leu->Arg

CONTACT		Heme contact
HEMATOLOGY		Moderately severe hemolytic anemia; Heinz bodies
ELECTROPHORESIS		Hb X moves slower than Hb A at alkaline pH
CHROMATOGRAPHY		Hb X elutes behind Hb A2 on a cation exchange HPLC column; the betaX and betaA chains separate on a reversed phase HPLC column (elution order: betaX, betaA, alpha)
STRUCTURE STUDIES		Tryptic digestion of betaX chain; separation of peptides by reversed phase HPLC or fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CTG->CGG at codon 88
FUNCTION STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in members of a Swedish family and a young South African female (her parents are both normal)
OTHER INFORMATION		Quantity in the heterozygote ~25%

REFERENCES
1.		Hollender, A., Lorkin, P.A., Lehmann, H., and Svenson, B.: Nature, 222:953, 1969.
2.		Bird, A.R., Elliot, T.E., Wilson, J.B., Webber, B.B., Kutlar, F., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 11:157, 1987.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.