Hb Aurora	beta139(H17)Asn->Tyr

CONTACT		Central cavity
HEMATOLOGY		Mild erythrocytosis in the heterozygote (PCV 0.49 l/l)
ELECTROPHORESIS		No separation by standard techniques at alkaline pH; Hb X occupies the position of Hb F on acid agar electrophoresis and on IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Not reported
DNA ANALYSES		An AAT->TAT mutation at codon 139
FUNCTION STUDIES		Increased oxygen affinity of whole blood
STABILITY		Normal
OCCURRENCE		Found in a 73-year-old Dutch female living in Canada
OTHER INFORMATION		Quantity of the variant estimated at ~50%; alpha-thal is absent

REFERENCES
1.		Lafferty, J., Ali, M., Matthew, K., Eng, B., Patterson, M., and Waye, J.S.: Hemoglobin, 19:335, 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.