Hb Ankara	beta10(A7)Ala->Asp

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slightly faster than Hb A on paper and starch gel at alkaline pH
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis; Edman degradation
DNA ANALYSES		Not reported; presumed mutation GCC->GAC at codon 10
FUNCTION STUDIES		Not determined
STABILITY		Stable
OCCURRENCE		Found in a Turkish and a few Japanese families
OTHER INFORMATION		Quantity in the heterozygote 42%

REFERENCES
1.		Arcasoy, A., Casey, R., Lehmann, H., Cavdar, A.O., and Berki, A.: FEBS Lett., 42:121, 1974.
2.		Hidaka, K., Iuchi, I., Shimasaki, S., Mizuta, W., Takatsuka, M., Mori, T., Tohdoh, A., and Matsuo, M.: Hemoglobin, 10:65, 1986.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.