Hb Alesha	beta67(E11)Val->Met

CONTACT		Heme contact
HEMATOLOGY		Inclusion body hemolytic anemia, reticulocytosis; no cyanosis; Heinz bodies; no methemoglobinemia
ELECTROPHORESIS		No separation by standard procedures
CHROMATOGRAPHY		Partial separation of Hb X and Hb A by cation exchange HPLC; no separation of betaX and betaA by reversed phase HPLC
STRUCTURE STUDIES		Not reported; identification through DNA analysis
DNA ANALYSES		A GTG->ATG mutation at codon 67
FUNCTION STUDIES		Slightly increased auto-oxidation
STABILITY		Unstable
OCCURRENCE		Found in a young Russian boy but not in his parents
OTHER INFORMATION		Quantity in the heterozygote 18-25

REFERENCES
1.		Molchanova, T.P., Postnikov, Yu.V., Pobedimskaya, D.D., Smetanina, N.S., Moschan, A.A., Kazanetz, E.G., Tokarev, Yu.N., and Huisman, T.H.J.: Hemoglobin, 17:217, 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.