Hb Alabama | beta39(C5)Gln->Lys |
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CONTACT | alpha1beta2 contact | ||
HEMATOLOGY | Mild anemia in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; Hb X moves to the position of Hb S | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-Sephadex chromatography; Hb X elutes between Hb A and Hb A2 | ||
STRUCTURE STUDIES | Tryptic digestion; cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAG->AAG at codon 39 | ||
FUNCTION STUDIES | Not performed | ||
STABILITY | Not performed | ||
OCCURRENCE | Found in a Black family from Alabama, USA | ||
OTHER INFORMATION | Quantity in the heterozygote 38% |
REFERENCES | |||
1. | Brimhall, B., Jones, R.T., Schneider, R.G., Hosty, T.S., Tomlin, G., and Atkins, R.: Biochim. Biophys. Acta, 379:28, 1975. |