Hb Zambia | alpha60(E9)Lys->Asn |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Only studied by paper electrophoresis; it moves faster than Hb A at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation AAG->AAC or AAT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in four unrelated families in Zambia | ||
OTHER INFORMATION | None |
REFERENCES | |||
1. | Barclay, G.P.T., Charlesworth, D., and Lehmann, H.: Br. Med. J., 4:595, 1969. |