Hb Yuda | alpha130(H13)Ala->Asp |
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CONTACT | Internal; central cavity | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X has a pI nearly the same as Hb A1c on IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | The alphaX chain was isolated by CM-cellulose chromatography; tryptic digestion; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GCT->GAT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Decreased oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a diabetic Japanese female | ||
OTHER INFORMATION | The alphaX chain accounts for ~30% of total alpha |
REFERENCES | |||
1. | Fujisawa, K., Hattori, Y., Ohba, Y., and Ando, S.: Hemoglobin, 16:435, 1992. |