Hb Winnipeg | alpha75(EF4)Asp->Tyr |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb A on paper and starch gel; moves between Hb S and Hb F on cellulose acetate and like Hb A on citrate agar | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAC->TAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a few Caucasian families in Canada and the United States | ||
OTHER INFORMATION | Quantity in heterozygotes 13-20% |
REFERENCES | |||
1. | Vella, F., Wiltshire, B., Lehmann, H., and Galbraith, P., Clin. Biochem., 6:66, 1973. | ||
2. | Nakatsuji, T., Abraham, B.L., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 7:105, 1983. |