Hb Tottori	alpha59(E8)Gly->Val

CONTACT		Internal
HEMATOLOGY		Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A at alkaline and acid pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GGC->GTC; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal oxygen affinity
STABILITY		Unstable
OCCURRENCE		Found in a Japanese family
OTHER INFORMATION		Quantity in heterozygotes 10-12%

REFERENCES
1.		Nakatsuji, T., Miwa, S., Ohba, Y., Miyaji, T., Matsumoto, N., and Matsuoka, I.: Hemoglobin, 5:427, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.