Hb Tokoname | alpha139(HC1)Lys->Thr |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X is more anodic than Hb A by IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin | ||
DNA ANALYSES | Not reported; presumed mutation AAA->ACA; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; decreased cooperativity; normal Bohr effect | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Japanese female | ||
OTHER INFORMATION | Quantity in the heterozygote about 25% |
REFERENCES | |||
1. | Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 7:85, 1983. |