Hb St. Claude | alpha127(H10)Lys->Thr |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves faster than Hb A at alkaline pH | ||
CHROMATOGRAPHY | Hb X and Hb A separate by cation and anion exchange chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by cation exchange chromatography; performic acid, chymotrypsin; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation AAG->ACG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a family of French-Canadian descent | ||
OTHER INFORMATION | Quantity in the heterozygote 27-29% |
REFERENCES | |||
1. | Vella, F., Galbraith, P., Wilson, J.B., Wong, S.C., Folger, G.C., and Huisman, T.H.J.: Biochim. Biophys. Acta, 365:318, 1974. |