Hb Spanish Town	alpha27(B8)Glu->Val

CONTACT		External; surface crevice
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves between Hb S and Hb F at alkaline pH; like Hb A at acidic pH
CHROMATOGRAPHY		The variant was isolated by anion exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->GTG; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal to mildly unstable
OCCURRENCE		Found in a Black Jamaican family
OTHER INFORMATION		Quantity in heterozygotes 11-12%

REFERENCES
1.		Ahern, E., Ahern, V., Holder, W., Palomino, E., Serjeant, G.R., Serjeant, B.E., Forbes, M., Brimhall, B., and Jones, R.T.: Biochim. Biophys. Acta, 427:530, 1976.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.