Hb Russ | alpha51(CE9)Gly->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; moves as Hb S on starch gel | ||
CHROMATOGRAPHY | Hb X and Hb A can be separated by cation and anion exchange chromatography | ||
STRUCTURE STUDIES | Tryptic peptides of the alpha chain were separated by cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GGC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in Caucasian families in the USA and in a Chinese family | ||
OTHER INFORMATION | Quantity in heterozygotes 10-13% |
REFERENCES | |||
1. | Reynolds, C.A. and Huisman, T.H.J.: Biochim. Biophys. Acta, 130:541, 1966. | ||
2. | Chen, S-S., Yang, K-G., Jia, P-C., Liang, C-C., Huang, S-L., Liang, J-T., Chen, Q., and Li, H-H.: Acta Biochim. Biophys. Sin., 15(4):339, 1983. |