Hb Reims | alpha23(B4)Glu->Gly |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves slower than Hb A at alkaline pH; good separation by IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis; sequencing of the alphaT-4 peptide | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GGG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Slightly unstable | ||
OCCURRENCE | Found in a 60-year-old French woman | ||
OTHER INFORMATION | Quantity in the heterozygote ~31% |
REFERENCES | |||
1. | Bardakdjian-Michau, J., Rosa, J., Galactéros, F., Lancelot, M., and Marquart, F.X.: Hemoglobin, 13:733, 1989. |