Hb Q-Iran | alpha75(EF4)Asp->His |
---|
CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb S at alkaline pH | ||
CHROMATOGRAPHY | Hb X and Hb A can be separated by cation and anion exchange HPLC | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAC->CAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Stable | ||
OCCURRENCE | Found in a few Iranian and Turkish families | ||
OTHER INFORMATION | Quantity in the heterozygote 17-19% |
REFERENCES | |||
1. | Lorkin, P.A., Charlesworth, D., Lehmann, H., Rahbar, S., Tuchinda, S., and Lie-Injo, L.E.: Br. J. Haematol., 19:117, 1970. | ||
2. | Lie-Injo, L.E., Dozy, A.M., Kan, Y.W., Lopes, M., and Todd, D.: Blood, 54:1407, 1979. | ||
3. | Aksoy, M., Gurgey, A., Altay, Ç., Kilinç, Y., Carstairs, K.C., Kutlar, A., Chen, S.S., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 10:215, 1986. |