Hb Port Phillip | alpha91(FG3)Leu->Pro |
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CONTACT | Heme and alpha1beta2 contacts | ||
HEMATOLOGY | Mild anemia; reticulocytosis in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb F on starch gel at alkaline pH | ||
CHROMATOGRAPHY | Hb X and Hb A separate incompletely on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CTT->CCT; alpha2 or alpha1T | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in a Chinese female | ||
OTHER INFORMATION | Quantity in the heterozygote about 7% |
REFERENCES | |||
1. | Brennan, S.O., Tauro, G.P., Melrose, W., and Carrell, R.W.: FEBS Lett., 81:115, 1977. |