Hb Oleander | alpha116(GH4)Glu->Gln |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves as Hb S at alkaline pH and as Hb A on citrate agar at acidic pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; glycinamidation; cation exchange chromatography; chymotrypsin; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->CAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Black family | ||
OTHER INFORMATION | Quantity in the heterozygote 22.3% |
REFERENCES | |||
1. | Schneider, R.G., Hightower, B., Carpentieri, U., Duerst, M.L., Shih, T.B., and Jones, R.T.: Hemoglobin, 6:465, 1982. |