Hb O-Padova | alpha30(B11)Glu->Lys |
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CONTACT | alpha1beta1 contact | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb C (closer to Hb C) on starch gel, cellulose acetate, and citrate agar at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex or DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting or on a reversed phase column; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->AAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in members of an Italian and a Turkish family | ||
OTHER INFORMATION | Quantity in heterozygotes 12.6-18% |
REFERENCES | |||
1. | Vettore, L., DeSandre, G., Dilorio, E.E., Winterhalter, K.H., Lang, A., and Lehmann, H.: Blood, 44:869, 1974. | ||
2. | Kilinç, Y., Kumi, M., Gurgey, A., Altay, Ç., Webber, B.B., Wilson, J.B., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 9:621, 1985. |