Hb Miyano | alpha41(C6)Thr->Ser |
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CONTACT | Internal; alpha1beta2 contact | ||
HEMATOLOGY | Erythrocytosis in the heterozygote | ||
ELECTROPHORESIS | Separation of Hb X and Hb A only by IEF | ||
CHROMATOGRAPHY | Hb X and Hb A could not be separated by either anion or cation exchange HPLC | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting on a cation exchange HPLC column; amino acid analysis; acid hydrolysis of the alphaT-6 peptide | ||
DNA ANALYSES | Not reported; presumed mutation ACC->TCC or AGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Japanese male blood donor, born in 1931 | ||
OTHER INFORMATION | None |
REFERENCES | |||
1. | Ohba, Y., Imai, K., Uenaka, R., Ami, M., Fujisawa, K., Itoh, K., Hirakawa, K., and Miyaji, T.: Hemoglobin, 13:637, 1989. |