Hb Melusine | alpha114(GH2)Pro->Ser |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | No separation except by IEF; Hb X moves slightly slower than Hb A | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | The alphaA and alphaX chain separates by reversed phase HPLC; the tryptic peptides of the AE-alphaX chain were separated by HPLC methodology; the alphaT-12B peptide was digested with S. aureus V8 protease; HPLC methodology; amino acid analysis; electro-spray mass spectrometry | ||
DNA ANALYSES | Not reported; presumed mutation CCC->TCC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in an Algerian male | ||
OTHER INFORMATION | The alphaX chain has a high hydrophobicity; quantity in the heterozygote is unknown |
REFERENCES | |||
1. | Wajcman, H., Kalmés, G., Groff, P., Promé, D., Riou, J., and Galacteros, F.: Hemoglobin, 17:397, 1993. |