Hb Loire | alpha88(F9)Ala->Ser |
---|
CONTACT | Internal | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | No separation of Hb X and Hb A by routine electropho-retic methods; it focuses between Hb A and Hb F (near Hb F) on IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Hb X was isolated by preparative IEF; the alphaX and beta chains were separated by CM-cellulose chromatography; the tryptic peptides were separated by reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GCG->TCG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity | ||
STABILITY | More stable than Hb A | ||
OCCURRENCE | Found in a family of Algerian-French descent | ||
OTHER INFORMATION | Quantity in heterozygotes 25-30% |
REFERENCES | |||
1. | Baklouti, F., Baudin-Chich, V., Kister, J., Marden, M., Teyssier, G., Poyart, C., Delaunay, J., and Wajcman, H.: Eur. J. Biochem., 177:307, 1988. |