Hb Lisbon | alpha23(B4)Glu->Asp |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | The best separation of Hb X and Hb A is by IEF; the electrophoretic pattern showed a slight decrease in pI | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GAT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a 31-year-old Portuguese male | ||
OTHER INFORMATION | Quantity in the heterozygote not reported |
REFERENCES | |||
1. | Wajcman, H., Bost, M., Blouquit, Y., Préhu, C., Riou, J., and Galacteros, F.: Hemoglobin, 18:427, 1994. |