Hb Lille | alpha74(EF3)Asp->Ala |
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CONTACT | External; near central cavity | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH; Hb X moves to the position of Hb S on cellulose acetate | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAC->GCC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in an Algerian female | ||
OTHER INFORMATION | Quantity in the heterozygote reported as 34% |
REFERENCES | |||
1. | Djoumessi, S., Rousseaux, J., Descamps, J., Goudemand, M., and Dautrevaux, M.: Hemoglobin, 5:475, 1981. |