Hb L-Persian Gulf | alpha57(E6)Gly->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | The slowly-moving variant separates from Hb A at alkaline pH; the two Hbs do not separate at low pH; Hb X moves between Hb S and Hb G on starch gel and paper | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GGC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a female living near the Persian Gulf | ||
OTHER INFORMATION | Quantity in the heterozygote about 18% |
REFERENCES | |||
1. | Rahbar, S., Kinderlerer, J.L., and Lehmann, H.: Acta Haematol., 42:169, 1969. |