Hb Kawachi | alpha44(CE2)Pro->Arg |
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CONTACT | External | ||
HEMATOLOGY | Not reported | ||
ELECTROPHORESIS | Hb A and Hb X separate at alkaline pH; Hb X is present between Hb A2 and Hb A on IEF | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CCG->CGG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity, reduced Bohr effect and cooperativity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in three members of a Japanese family | ||
OTHER INFORMATION | Quantity in heterozygotes 26-27% |
REFERENCES | |||
1. | Harano, T., Harano, K., Ueda, S., Shibata, S., Imai, K., Ohba, Y., Shinohara, T., Horio, S., Nishioka, K., and Shirotani, H.: Hemoglobin, 6:43, 1982. |