Hb Karachi	alpha5(A3)Ala->Pro

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb A in cellulose acetate at pH 8.4
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GCC->CCC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		In a healthy Pakistani male
OTHER INFORMATION		None

REFERENCES
1.		Ahmad, A., Naqvi, S., Ehsanullah, S., and Zaidi, Z.H.: J. Pakistani Med. Assoc., 36:206, 1986.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.