Hb J-Wenchang-Wuming | alpha11(A9)Lys->Gln |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves faster than Hb A at alkaline pH (8.6) | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation AAG->CAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in five persons in a Chinese family | ||
OTHER INFORMATION | Quantity in heterozygotes 20% |
REFERENCES | |||
1. | Chen, S-S., Liang, L-L., Jia, P-C., Yang, K-G., Chen, L-C., and Chen, L-F.: Zhongguo Kexue (series B), 26(3):243, 1983. | ||
2. | Zeng, Y-T., Huang, S-Z., Liang, X., Long, G-F., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 5:679, 1981. |