Hb J-Tashikuergan | alpha19(AB1)Ala->Glu |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X separates from Hb A as a fast moving band on cellulose acetate at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GCG->GAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in three families of the Tajike ethnic group; emigrés from Afghanistan | ||
OTHER INFORMATION | Quantity in heterozygotes 18.9-22.7% |
REFERENCES | |||
1. | Li, H., Liu, D., Liu, Z., Li, P., Li, L., Chen, J., and Hou, S.: Hemoglobin, 8:391, 1984. |