Hb J-Nyanza | alpha21(B2)Ala->Asp |
---|
CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves faster than Hb A on paper at alkaline pH (8.9) | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GCT->GAT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a family from Western Kenya | ||
OTHER INFORMATION | Quantity in heterozygotes as high as 35% because of a co-existing alpha-thal |
REFERENCES | |||
1. | Kendall, A.G., Barr, R.D., Lang, A., and Lehmann, H.: Biochim. Biophys. Acta, 310:357, 1973. |